University of Florida Research Foundation, Incorporated

Other

Quick-med Technologies, Inc.

Louisiana State University and Agricultural & Mechanical College

Glycomed, Inc.

Sharklet Technologies, Inc.

Chiron Ophthalmics, Inc.

The Institute of Ophthalmology

Moorfields Eye Hospital Nhs Trust

Gregory Schultz

David S. Lerner

Gregory Scott Schultz

Christopher D Batich

Daniel J Gibson

Alfred Samuel Lewin

David Clair Bloom

Richard E Galardy

Damian Grobelny

Sonal Sanjeev Tuli

Priscilla Lorraine Phillips

Peng Tee Khaw

Gerald M Olderman

David S Lerner

John H Musser

William Toreki

Kevin R Holme

Weihong Tan

Daniel E Levy

Donna M Neumann

Bruce A Mast

Edith Marion Sampson

Jia Liu

John I Azeke

Zachary L Watson

Cho Tang

Asaad Nematalia

Anthony B Brennan

Bradley Jay Willenberg

Chelsea Marie Magin

Erich T Wyckoff

Timothy D Blalock

Dylan Burton Neale

Sonal Sanjeen Tuli

Robert W Shimizu

Olajompo B Moloye

Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Method for delivering RNA to neurons to treat herpes infections

Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

Bilayered devices for enhanced healing

The subject invention provides novel devices and methods for the detection and quantification of neutrophil elastase activity in biological samples.

Rapid bed-side measurement of neutrophil elastase activity in biological fluids

Provided herein are laparoscopic tissue removal systems, components, and uses thereof.

Laparoscopic tissue removal system

The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.

Materials and methods for assessing and mapping microbes and microbial biofilms on wounds

The subject invention presides novel devices and methods for the measurement of nitric oxide in biological samples, including wound fluid samples. These advantageous devices and methods can be used for clinicians to monitor the wound's nitric oxide metabolism and/or response to treatment.

Materials and methods for measuring nitric oxide levels in biological fluids

Electromotive delivery of macromolecules can be provided using a delivery device including a first chamber for contacting a macromolecule delivery medium to a surface of a tissue or other anatomy of a patient; and a second chamber for contacting a receiving medium to the patient. A first electrode can be disposed in the first chamber so as to not directly contact the macromolecule delivery medium. A second medium having a buffering agent can be used to keep the first electrode from coming into direct contact with the macromolecule delivery medium. A second electrode can be disposed within the receiving medium in the second chamber such that the second electrode does not directly contact the patient. An electric field can be generated using the first and second electrodes in order to cause the macromolecule delivery medium to move into the tissue of interest from the first chamber of the delivery device.

Method and device for electromotive delivery of macromolecules into tissue

The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.

Devices for the detection of the presence and/or activity of proteases in biological samples

This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.

Antimicrobial bandage material comprising superabsorbent and non-superabsorbent layers

Hammerhead ribozymes that target components critical to HSV replication (ICP4, U20, U30, and U54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.

Herpesvirus ribozymes and vectors

Materials with covalently-bonded, nonleachable, polymeric antimicrobial surfaces

Methods and compositions for treating scarring conditions associated with increased expression of connective tissue growth factor (CTGF). Aspects of the invention include ribozymes that cleave mRNA targets required for CTGF expression, cells containing anti-CTGF ribozymes and vectored anti-CTGF ribozymes suitable for delivery to cellular targets capable of CTGF expression.

Anti-scarring ribozymes and methods

Growing community of inventors

Gainesville, FL, United States of America

Gregory Scott Schultz