University of California

California Institute of Technology

Boston Scientific Corporation

Gregory S Kelley

Arash Kheradvar

Morteza Gharib

Ricardo David Roman

Herbert R Radisch, Jr

Show-Mean Wu

Loren M Crow

Steven A McAuley

Karen M Cheves

Mohammad Sarraf

Herbert R Radisch

Steven A Mcauley

Jr Herbert R Radisch

A medical device delivery system including a delivery sheath that includes an internal lumen, and a plurality of delivery arms contained within the internal lumen of the delivery sheath and extending along a longitudinal axis of the internal lumen of the delivery sheath, wherein distal ends of the delivery arms include fasteners configured to engage with a basal structure of a medical device and a apical structure of the medical device, wherein the delivery arms are attached to delivery arm controls that are configured to advance the delivery arms and the medical device attached thereto out from a distal end of the delivery sheath, and removable release wires or release lines configured to engage with the fasteners to hold the basal structure and the apical structure in place at the fasteners. Also disclosed are methods of delivering a medical device to a subject including inserting a distal end of the medical device delivery system through an incision in the skin of subject, and deploying a medical device engaged with the delivery arms of the medical delivery system to within the body of the subject.

Percutaneous medical device delivery system

A percutaneous heart valve delivery system including a valve delivery catheter coupled with a first inflatable balloon positioned at a distal end of the valve delivery catheter, wherein the first inflatable balloon is configured to fracture a previously implanted prosthetic heart valve; and a replacement transcatheter heart valve positioned proximal to the first inflatable balloon, wherein the replacement transcatheter heart valve is configured to be implanted subsequently within the previously implanted, fractured prosthetic heart valve, following fracture of the previously implanted heart valve without withdrawal of the percutaneous heart valve delivery system. Also disclosed are methods of implantation of a new heart valve within a previously implanted prosthetic heart valve and methods of valvuloplasty of a native heart valve.

Percutaneous heart valve delivery and implantation system enabling fracture of a previously present valve

A gimbal handle assembly including: an inner gimbal and an outer gimbal that are concentrically linked and have pivot axes that are orthogonal relative to each other, a spool coupled to and rotatable around the outer gimbal, and a plurality of draw lines attached to the spool in a circumferential configuration, wherein rotation of the spool and/or rotation of the spool and the outer and inner gimbals increases or reduces tension in the draw lines. Also disclosed are a transcatheter valve delivery assembly that includes the gimbal handle assembly, a multi-lumen catheter, a sleeve attached to a distal end of the multi-lumen catheter, and a transcatheter heart valve including an expandable valve frame. Methods of delivering the transcatheter valve to a subject are described, wherein pitch and yaw orientations of the transcatheter valve can be precisely controlled with enhanced degrees of freedom.

Delivery system for transcatheter valves

Described is a collapsible atrial cage for percutaneous delivery and implantation of an atrioventricular valve within an atrium of the heart. The atrial cage includes an atrial portion and a ventricular portion. The ventricular portion is attached with and separated from the atrial portion by a valve juncture portion. Notably, the cage includes at least one interlock shaped to lock with and secure an atrioventricular valve proximate the valve juncture portion. Thus, when deployed and expanded, the atrioventricular valve is secured at the atrioventricular juncture.

Atrial cage for placement, securing and anchoring of atrioventricular valves

Described is an apparatus for transcatheter detachment of a stent from a delivery device. A single-ended draw line with loops is inserted through a restraining hole in a glide and a release line is inserted through the loops. The single-ended draw line is thus prevented from pulling through the restraining hole while the release line is through the loops. The single-ended draw line is free to pass through the restraining hole after the release line is pulled out of the loops and thereafter pulled free of stent holes formed through a stent, thereby detaching the stent at a desired location.

Delivery system for transcatheter detachment of a stent from the delivery device using single-ended draw lines

Described is a delivery system for percutaneous delivery and implantation of a heart valve. The delivery system includes a handle with a sheath extending therefrom. A splay shaft extends from the handle through the sheath. At least two arms extend from the handle through the splay shaft. The at least two arms are operable for holding a heart valve. A sheath controller is housed within the handle and is operable for selectively advancing or retracting the sheath to constrain or expose a heart valve as attached with the at least two arms. A splay shaft controller is housed within the handle for allowing the user to selectively advance or retract the splay shaft to constrain or expose the at least two arms. Finally, a valve release is attached with the handle to allow a user to selectively release a heart valve as attached with the at least two arms.

Delivery system for percutaneous delivery and implantation of atrioventricular heart valves

Described is an apparatus for transcatheter detachment of a stent from a delivery device. A braided suture with an opening is inserted through a restraining hole in a glide (the opening is secured on one side by a knot or a series of knots) and a release line is inserted through the braided suture opening. The braided suture is thus prevented from pulling through the restraining hole while the release line is through the opening. The braided suture is free to pass through the restraining hole after the release line is pulled out of the opening and thereafter pulled free of stent holes formed through a stent, thereby detaching the stent at a desired location.

Delivery system for transcatheter detachment of a stent from the delivery device

Improved catheter devices for delivery, repositioning and/or percutaneous retrieval of percutaneously implanted heart valves are described, including a medical device handle that provides an array of features helpful in conducting a percutaneous heart valve implantation procedure while variously enabling radial expansion or contraction and/or lateral positioning control over the heart valve during the medical procedure.

Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves

Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.

Growing community of inventors

Santee, CA, United States of America

Gregory S Kelley