Gpi Nil Holdings Inc.

Guilford Pharmaceuticals, Inc.

Eisai Inc.

The Johns Hopkins University

Gliamed, Inc.

Other

Otsuka Pharmaceutical Company, Limited

Artesian Therapeutics, Inc.

Gpi Nil Holdindgs, Inc.

Gpi Nil Holding, Inc.

Gregory S Hamilton

Joseph P Steiner

Jia-He Li

Douglas T Ross

Hansj&ouml;rg Sauer

Wei Huang

Dana Victor Ferraris

Bridget Duvall

Solomon H Snyder

Yong-Qian Wu

Ted M Dawson

Mark Vaal

Sergei Belyakov

Mark Henry Norman

Takashi Tsukamoto

Rena S Lapidus

Eric S Burak

Mark J Vaal

Ling Wei

David Limburg

Hansjörg Sauer

Jai-He Li

Waclaw J Rzeszotarski

Maria E Guzewska

Harry Jefferson Leighton

John W Ferkany

Suzanne R Ellenberger

Raymond J Patch

Douglas Wilkinson

Chi Choi

Edward W Karbon, Jr

Sergel Belyakov

Rena Lapidus

The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.

Certain compounds, compositions and methods

Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.

Compositions and methods for treating cancer

Provided herein are methods of treating cancer comprising administering decitabine in combination with compounds that inhibit the deamination enzyme responsible for the inactivation of decitabine.

This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Small molecule inhibitors of rotamase enzyme activity

Small molecule rotamase enzyme inhibitors

This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.

N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres

This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked sulfonamides of heterocyclic thioesters.

N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders

This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic esters and amides.

Heterocyclic esters or amides for vision and memory disorders

This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Growing community of inventors

Catonsville, MD, United States of America

Gregory S Hamilton