University of Iowa Research Foundation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Columbia University

University of Utah Research Foundation

Gregory S Hageman

Robert F Mullins

Michael C Dean

Rando L Allikmets

Albert M Gold

Richard J Smith

Markus Kuehn

Christian Matthew Pappas

David Hutcheson

The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.

Methods and reagents for treatment of age-related macular degeneration

Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.

Variants in complement regulatory genes predict age-related macular degeneration

Therapeutic compositions for age-related macular degeneration comprising a complement factor H with isoleucine at residue 62 and tyrosine at residue 402

Complement factor H for diagnosis of age-related macular degeneration

Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating patients to alleviate symptoms of the disease, prevent or delay its onset, or inhibit its progression. The inventions are based on the discovery that persons with a genome having a deletion of the CFHR-1 and/or CFHR-3 gene, which normally lie on human chromosome 1 between DNA encoding CFH and CFHR-4, are at reduced risk of developing AMD, and elevated risk of developing vascular disease such as aneurysm.

Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration

Methods for treatment of age-related macular degeneration

The invention relates to methods for diagnosing and treating macular degeneration-related disorders. The invention also related to methods for identifying genes that cause macular degeneration-related disorders.

Diagnostics and therapeutics for macular degeneration-related disorders

The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.

Methods and compositions for treating ocular disorders such as retinal detachment and macular degeneration and methods and compositions for prognosing or diagnosing retinal detachment or macular degeneration in a subject are disclosed.

Nucleic acids encoding interphotoreceptor matrix proteins

The invention relates to diagnostics and therapeutics and animal models for macular degeneration, specifically as they relate to the association described herein between macular degeneration and arterial wall disruptive disorders. In one embodiment, the invention provides kits and methods for diagnosing macular degeneration comprising identifying a marker for an arterial wall disruptive disorder, including an aneurysm. In one embodiment, the invention provides therapeutics for treating macular degeneration comprising delivering to a subject an agent useful for treating an arterial wall disruptive disorder, including an aneurysm.

Growing community of inventors

Coralville, IA, United States of America

Gregory S Hageman