Boehringer Ingelheim Pharmaceuticals, Inc.

Gregory Paul Roth

Christopher Ronald Sarko

Daniel R Goldberg

Neil Moss

Roger John Snow

Charles Lawrence Cywin

Abdelhakim Hammach

Steven S Pullen

Ming-Hong Hao

Hidenori Takahashi

Lei Qiao

Alan David Swinamer

Zhaoming Xiong

Ho Yin Lo

Donghong Amy Gao

Peter Allen Nemoto

Michael Peter Winters

Brian Nicholas Cook

Pingrong Liu

Fariba Soleymanzadeh

Joerg Bentzien

Ji Wang

Victor Marc Kamhi

Kevin Chungeng Qian

Mark Stephen Ralph

Roman Wolfgang Fleck

Antonio J Barbosa

Roy Lewis Barr

Kevin J Moriarty

Antonio Jose Del Moral Barbosa, Jr

Thomas James Baiga

Noel Stewart Wilson

Jinbo Lee

John Landi

Andre White

Junefredo Fajardo Apon

Steven Russell Bush

Disclosed are amide compounds of formula (I): wherein Ar, Q, Y and R-Rof formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases

Disclosed are substituted benzimidazole compounds of formula (I): wherein R, R, R, Rand Xare defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Substituted benzimidazole compounds

Disclosed are benzimidazolone compounds of formulas (I) & (II): wherein R, R, R, R, R, X, L, m, n and t are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds 

Heterocyclic compounds

Disclosed is an apparatus for automated synthesis containing a shaker deck with a plurality of reaction blocks containing a plurality of reaction wells, an arm containing an array of extending units capable of actuating physical steps along a plurality of axes of each reaction block, each reaction block being situated on a turntable, each turntable being further capable of rotating the reaction block along a central axis. Also disclosed are methods of preparing a peptide, oligonucleotide an small molecules using the apparatus.

Apparatus for automated synthesis

This invention relates to process for asymmetrically producing enantiomerically pure .alpha.-cycloalkylalkyl substitututed methanamines from .alpha.-pinene. One key step of the process of this invention utilizes the oxidation product of .alpha.-pinene, hydroxy pinanone, as a chiral auxiliary to direct the stereoselective alkylation of the corresponding ketimine. This invention also relates to key intermediates useful in the processes referred to herein.

Asymmetric synthesis of .alpha.-cycloalkylalkyl substituted methanamines

Growing community of inventors

New Milford, CT, United States of America

Gregory Paul Roth