Mirabilis Medica, Inc.

Liposonix, Inc.

Medicis Technologies Corporation

University of Washington

Doosan Gridtech, Inc.

Matchstick Technologies, Inc.

Mirabillis Medica, Inc.

Gregory Paul Darlington

Jens Ulrich Quistgaard

Justin Reed

Charles S Desilets

Charles Dale Emery

Tim Etchells

Jessica E Parsons

Michael J Connolly

John Russell Murkowski

Roland Horth

Barry Friemel

Michael P H Lau

Lee David Dunbar

George Barrett

Adam Lee Smith

Zihong Guo

David Kaplan

Scott Craig Thielman

Peter John Kaczkowski

Kathryn Ann Stecco

Ethan P Albright

Blake R Stancik

Robert H Pedersen

Karol Bomsztyk

John Kucewicz

Joshua I Kaplan

Francesco P Curra

Gregory T Wing

Troy Brown

Daniel B Phillips

Jody Lloyd Johnson

Howard Holman

Daniel S Mar

Justin A Reed

Jens Urich Quistgaard

Michael PH Lau

Charles D Emery

A plate handling device includes a base having a first and second base member configured to hold a plate. The base is adapted to expand and contract to secure the plate to the plate handling device. The plate handling device includes a handle having an upper end and a lower end, and the handle is adapted to actuate the expanding and contracting of the base to secure and hold the plate. An outer handle member is fixedly attached to the first base member. A user interface member is fixedly attached to the second base member, is pivotably attached to the lower end of the handle, and is pivotably receivable in portions of the outer handle member.

Plate handling devices and methods for plate handling of analytical and culture vessels

The present technology is generally directed to filtering systems and methods for suppression of reverberation artifacts in ultrasound images. In some embodiments, a method of obtaining a filtered ultrasound image includes taking a first ultrasound image of a target tissue using an applicator. At least a portion of the applicator is moved such that the reverberation artifact ultrasound path length changes relative to the first position of the applicator. A second ultrasound image of the target tissue is then taken. The first and second ultrasound images are synthesized using at least one filtering method. The filtering method attenuates or removes reverberation artifacts in the synthesized ultrasound image.

Filtering systems and methods for supression of non-stationary reverberation in ultrasound images

A system and method for adjusting or selecting the treatment parameters for HIFU signals to treat a target treatment site, and/or to aid in visualizing the likely degree and location of HIFU effects on patient tissue. The system transmits one or more test signals into patient tissue and receives signals created in response to the test signals. The signals are analyzed to determine a response curve of how a characteristic of the signal varies with the one or more test signals. The response curve of the detected signals is used to select a treatment parameter.

Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics

A method and system for treating a desired volume of tissue using HIFU or other energy modality includes ablating a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In at least one embodiment, the elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ. The elemental treatment volumes are created by distributing HIFU energy in multiple doses with repeated passes of the focal zone of the HIFU transducer in a trajectory over or along a perimeter of each elemental treatment volume.

System for treating a volume of tissue with high intensity focused ultrasound

A system and method for providing real-time, image-guided high intensity focused ultrasound (HIFU) targeting and treatment of tissue. In one embodiment, the system includes an HIFU applicator and a user interface with a touchscreen display for three-dimensional visualization of the tissue. Image frames displayed on the user interface depict real-time images of the tissue, including an image parallel to a feature of the applicator and an image orthogonal to the parallel image. Reference lines may be sketched using the touchscreen and displayed on the image frames. In one embodiment, tissue boundaries are detected and marked on the image frames, either by the user or automatically by the system. In another embodiment, the user interface includes a footswitch for the user to interact with the system. In another embodiment, the system includes an ultrasound imaging component configured to undock from the system for use as a stand-alone ultrasound imaging device.

Human interface and device for ultrasound guided treatment

An applicator for providing HIFU therapy to a patient includes a HIFU transducer that is rotatably coupled to a frame. In one embodiment, the rotatable coupling is configured such that the HIFU transducer can be mechanically oriented to position a focal zone of the HIFU transducer at any desired location in a treatment volume radially outward from a longitudinal axis of the applicator while the HIFU transducer remains within a housing that is not more than a defined percentage (e.g., 50%) larger than the maximum diameter of the HIFU transducer. In one embodiment, the HIFU transducer is rotatably coupled to the frame with a ball and socket joint. In another embodiment, the HIFU transducer is rotatably coupled to the frame with an offset gimble assembly. A pair of linear actuators and drive shafts engage the HIFU transducer to orient HIFU transducer in a desired direction.

HIFU applicator

An energy storage system includes modular energy storage equipment that may be connected to an external system, such as a power grid. In at least one embodiment, the energy storage system includes a power transfer control system comprising a power transfer network and a processing module or controller. The power transfer network has a first interface coupleable to one or more energy storage units and a second interface coupleable to one or more power conversion units. One or more conductors in the power transfer network are selectively coupleable to the first interface and the second interface for transferring power between the energy storage units and the power conversion units based at least in part on information indicating a power or energy supply or demand of an external system or information indicating an amount of energy stored in the energy storage units. The energy storage system is scalable for different implementations.

Modular energy storage system

A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.

Methods and apparatus are described for coupling a high intensity focused ultrasound transducer to a skin surface using water as a coupling agent.

Methods and apparatus for coupling a HIFU transducer to a skin surface

Method and apparatus for treating tissues with HIFU

HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.

Method and apparatus for feedback control of HIFU treatments

A two-stage control system is disclosed being made of a first control means for providing command and control of a robotic arm, and a second control means for the control and movement of a therapy device, such as an ultrasound transducer. The therapy device is positioned within a therapy head. The therapy head is attached to the distal end of the robotic arm. The two-stage control system provides for a macro and micro level of control for the therapy device during a therapy procedure.

Articulating arm for medical procedures

A system and method for dynamically adjusting the energy of HIFU signals delivered to a patient, and/or to aid in visualizing the likely degree and location of HIFU effects on patient tissue. The system transmits a HIFU signal into a patient and receives echoes therefrom. The echo signals are analyzed to determine the energy of the signals in a first range, such as at one or more harmonics and/or sub-harmonics of the fundamental frequency of the HIFU signal, and energy of the echo signals in a second range such as at the fundamental frequency of the HIFU signal. Based on the comparison, the energy and/or focus of the HIFU signals delivered to the patient is adjusted. An image of the compared echo signal powers in two or more frequency ranges may also be displayed for a user or used to adjust the focus point of the HIFU signals.

Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals

A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.

Methods and apparatus for engagement and coupling of an intracavitory imaging and high intensity focused ultrasound probe

Growing community of inventors

Snohomish, WA, United States of America

Gregory Paul Darlington