Takeda Pharmaceutical Company Limited

Dyax Corporation

Gregory P Conley

Andrew Nixon

Daniel J Sexton

Burt Adelman

Jon A Kenniston

Ryan Faucette

Christopher TenHoor

Stephen R Comeau

Shauna Mason

Niksa Kastrapeli

Kristopher Kopacz

Allison P Lindberg

Yung Chyung

Christopher Tenhoor

Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.

Assays for determining plasma kallikrein system biomarkers

Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e.g., hereditary angioedema or thrombosis.

Bispecific antibodies against plasma kallikrein and factor XII

Disclosed herein are compositions comprising one or more antibodies that specifically bind active plasma kallikrein (e.g., human plasma kallikrein) and methods of using such compositions for the treatment of retinal diseases, such as diabetic macular edema.

Compositions and methods for treatment of diabetic macular edema

Bispecific antibodies against plasma kallikrein and Factor XII

The present disclosure provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.

Methods of determining levels of cleaved and/or intact kininogen

Growing community of inventors

Arlington, MA, United States of America

Gregory P Conley