University of Massachusetts

University of Pennsylvania

Cellceutix Corporation

Michael L. Klein

Gregory N. Tew

William F. Degrado

Gregory N Tew

William F DeGrado

Dahui Liu

Michael L Klein

Jing Yuan

Gregory J Gabriel

Arife Ozgul Tezgel

Abhigyan Som

Sungwook Choi

William F Degrado

Ahmad E Madkour

Karen Lienkamp

Ashlan Marie Musante

Alfred J Crosby

Richard W Scott

Xiaodong Fan

Lisa M Minter

Melissa A Lackey

Jun Cui

Yan Li

Catherine N Walker

Hitesh Thaker

Raja Shunmugam

Wenxi Pan

Ahmad Emad-Eldin Madkour

Sterling Fitzgerald Alfred

Paralee Patten King

Semra Colak

Emrah Ilker Ozay

Coralie M Backlund

Michael L University Of Pennsylvania Klein

William F University Of Pennsylvania Degrado

The invention provides compositions and methods for cytosolic delivery of peptides and antigens as well as concomitant delivery of antigens and agonists via poly-norbornene-based protein transduction domain mimics.

Cytosolic delivery of peptides using protein transduction domain mimics

The disclosure provides an ex vivo method to prepare regulatory T cells, a population of regulatory T cells with enhanced properties and methods of using the population or complexes useful to induce Tregs in a mammal. The ex vivo methods allows for the generation and expansion of super regulatory T cells for the prevention, inhibition or treatment of autoimmune disorders.

Ex vivo method of generating super regulatory T cells for the prevention of autoimmune disease

The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use.

Protein transduction domains mimics

The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or ainfection; inhibiting the growth of aspecies; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

Cyclic compounds and methods of making and using the same

The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

Facially amphiphilic polymers and oligomers and uses thereof

The invention provides highly resilient synthetic hydrogels, which can be prepared, for example, by using the efficient thiol-norbornene chemistry to cross-link hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polydimethylsiloxane (PDMS) polymer chains. The simple hydrogel system with enhanced mechanical properties is useful in many applications, including in the biomedical field and in the design of protective and corrective wear.

Telechelic based networks from novel macromonomers, compositions, preparation and uses thereof

Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polmers to a solid support. Utility as a contact disinfectant is disclosed.

Facially amphiphilic polymers as anti-infective agents

The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.

Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof

The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number of norbornene-based building blocks and/or enable easy and independent variation of hydrophobic and hydrophilic groups in the monomer units and/or along the polymeric backbone to finetune and select desirable properties of the polymers.

Antimicrobial polymers

Terpyridine-substituted compounds, compositions and/or related methods, as can be used to selectively detect a wide range of analytes.

Terpyridine-substituted compounds and related selective detection methods

The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof.

Water-soluble and water-insoluble, ring opening metathesis polymerization products, monomers and related methods

Growing community of inventors

Amherst, MA, United States of America

Gregory N Tew