Seres Therapeutics, Inc.

Seres Health, Inc.

Sample6 Technologies, Inc.

Gregory McKenzie

David N Cook

David Arthur Berry

John Grant Aunins

Geoffrey Von Maltzahn

Matthew R Henn

Brian Goodman

Marin Vulic

Jonathan Winkler

Mary-Jane Lombardo Mckenzie

Mary-Jane Lombardo McKenzie

Jason Wyatt Holder

Toshiro Kendrick Ohsumi

Anthony Mario D'Onofrio

Michael Koeris

Daniel Robert Brownell

Han Zhang

Brett Chevalier

Timothy Kuan Ta Lu

Edward J O'Brien

Madhumitha Nandakumar

Alice Peiyu Liou

Elizabeth Moritz Halvorsen

Asuncion Martinez

Jennifer Wortman

Julie Button

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.

Methods for treatment of Clostridium difficile infection or recurrence or symptoms thereof

The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.

Compositions and methods for treating cholestatic disease

Compositions for methods of preventing or reducing pathogenic bacterial growth, proliferation, and/or colonization are described containing one or more types of non-pathogenic bacteria to be introduced into the gastrointestinal tract and effectively compete with pathogenic bacteria for monomeric or polymeric carbohydrate nutrients, and/or amino acid nutrients, and/or vitamin nutrients.

Compositions and methods for inhibition of pathogenic bacterial growth

Compositions and methods

This disclosure provided methods of cloning a phage genome. Also provided are methods of making a recombinant phage genome. In some embodiments the phage genome is engineered to comprise a heterologous nucleic acid sequence, for example a sequence comprising an open reading frame. In some embodiments the phage genome is cloned in a yeast artificial chromosome. Recombinant phage genomes and recombinant phage are also provided. In some embodiments the methods are high throughput methods such as methods of making a plurality of recombinant phage genomes or recombinant phage. Collections of recombinant phage genomes and recombinant phage are also provided.

Recombinant phage and methods

Growing community of inventors

Arlington, MA, United States of America

Gregory McKenzie