Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

Other

Frommer Lawrence & Huag Llp

Gregory M Shutske

Kevin J Kapples

John D Tomer, Iv

Richard C Effland

Brian S Freed

R Richard Hamer

Frank A Pierrat

Linda L Setescak

Peter A Nemoto

Nicholas J Hrib

Richard C Allen

John G Jurcak

David G Wettlaufer

David M Fink

Barbara E Kurys

John Dick Tomer

Lawrence L Martin

Joseph T Klein

Grover C Helsley

Thomas B Lee

Gregory M Jobin

There are disclosed compounds having the formula

9-hydroxyamino tetrahydroacridine and related compounds

There are disclosed compounds having the formula ##STR1## wherein n is 1-4; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.2 or --NR.sub.3 R.sub.4 where R.sub.2 is hydrogen or loweralkyl, and R.sub.3 and R.sub.4 are independently hydrogen, loweralkyl or cycloalkyl; R is hydrogen, loweralkyl or loweralkylcarbonyl; and R.sub.1 is hydrogen, loweralkyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, furylloweralkyl, thienylloweralkyl, pyridinylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof which are useful for enhancing memory.

There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antienmtics, and for the treatment of personality disorders such as obsessive compulsive disorder.

Substituted pyridylamino indoles

Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.

Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles

2,3-dihydro-1H-isoindole derivatives of the formula ##STR1## where R.sub.1 -R.sub.5 and X are defined herein which are useful as serotonin reuptake inhibitors are disclosed. As such, these compounds may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.

2,3-dihydro-1H-isoindole derivatives

2,3-dihydro-1H-isoindole derivatives and their use as serotonin reuptake

2, 3-dihydro-1H-isoindole derivatives and their use as serotonin

There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

Substituted-4-amino-3-pyridonols

Substituted-4-amino-3-pyridinols

Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.

Aminoalkyloximers

Pyridiniminyl-1,2-benzisothiazoles

Aminoalkyloximes

Growing community of inventors

Flemington, NJ, United States of America

Gregory M Shutske