Barnes Jewish Hospital

Washington University

Bristol-myers Squibb Medical Imaging, Inc.

The Dow Chemical Company

Northwestern University

Koninklijke Philips Corporation N.V.

Monsanto Company

The Jewish Hospital of St. Louis

Samuel A. Wickline

Gregory M. Lanza

Gregory M Lanza

Samuel A Wickline

Dipanjan Pan

Garry E Kiefer

Phillip S Athey

Paul H Schlesinger

Allan Doctor

Philip C Spinella

Neelesh R Soman

Tom Harris

Samuel I Achilefu

Gyongyi Gulyas

Melvin E Klegerman

Grace Hufang Cui

Roland Proksa

Michael J Vonesh

Ewald Roessl

Robert Manzke

Axel Thran

Billy D Vineyard

Carsten Oliver Schirra

Hua Pan

Michael S Hughes

Mladen Victor Wickerhauser

David D McPherson

Bonnie J Kane

M Hayat Alkan-Onyuksel

Sasha E Murer

Melvin J DeGeeter

David L McPherson

M Hayat Onyuksel

Christopher S Hall

John McCarthy

Angana Senpan

The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.

Prodrug compositions, prodrug nanoparticles, and methods of use thereof

The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest, such as a biomarker of a disease or disorder.

Homing agents

A method includes analyzing a spectral projection image of a portion of a subject, generating a value quantifying an amount of a target specific contrast material in a region of interest of the spectral projection image, and generating a signal indicative of a presence of the target in response to the value satisfying a predetermined threshold level.

Spectral imaging

The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.

Blood substitute composition and method of use

Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents.

The present invention provides nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to deliver therapeutic agents and/or imaging agents.

Ligand directed toroidal nanoparticles for therapy and diagnostic imaging

The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.

Particles for imaging

The present invention relates to methods for improving muscle strength and treating muscular dystrophy.

Methods for improving muscle strength

The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.

Universal anchor peptide for nanoparticles

Growing community of inventors

St. Louis, MO, United States of America

Gregory M Lanza