University of Pittsburgh

Gregory M Constantine

Yoram Vodovotz

Qi Mi

David Okonkwo

Maxim Mikheev

Alexey Solovyev

Jorg Gerlach

Timothy R Billiar

Lukas Schimunek

Rami Namas

Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.

Time window-based platform for the rapid stratification of blunt trauma patients into distinct outcome cohorts

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Self-regulating device for modulating inflammation

Growing community of inventors

Baden, PA, United States of America

Gregory M Constantine