University of California

The United States Government As Represented by the Department of Veterans Affairs

The Salk Institute for Biological Studies

Gregory M Cole

Nagichettiar Satyamurthy

Jorge R Barrio

Gary W Small

Sung-Cheng Huang

Andrej Petric

Sally A Frautschy

David R Schubert

Pamela A Maher

Nutraceutical formulations that improve cognitive function in adults diagnosed with neurodegenerative disease are provided, which comprise a combination of fisetin and DHA.

Medical food for cognitive decline

Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor. A method of treating Alzheimer's and other age-related diseases by administering such a composition is also provided.

Bioavailable curcuminoid formulations for treating Alzheimer's disease and other age-related disorders

Compositions useful for labeling &#x3b2;-amyloid plaques and neurofibrillary tangles are provided. The compositions comprises compounds of formula (I): wherein Ris selected from the group consisting of &#x2014;C(O)-alkyl, &#x2014;C(O)-alkylenyl-R, &#x2014;C(O)O-alkyl, &#x2014;C(O)O-alkylenyl-R, &#x2014;C&#x2550;C(CN)-alkyl, &#x2014;C&#x2550;C(CN)-alkylenyl-R, wherein Ris a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; Ris a radical selected from the group consisting of &#x2014;NH, &#x2014;OH, &#x2014;SH, &#x2014;NH-alkyl, &#x2014;NHR, &#x2014;NH-alkylenyl-R, &#x2014;O-alkyl, &#x2014;O-alkylenyl-R, &#x2014;S-alkyl, and &#x2014;S-alkylenyl-R; Ris a radical selected from the group consisting of &#x2014;CN, &#x2014;COOH, &#x2014;C(O)O-alkyl, &#x2014;C(O)O-alkylenyl-R, &#x2014;C(O)-alkyl, &#x2014;C(O)-alkylenyl-R, &#x2014;C(O)-halogen, &#x2014;C(O)NH-alkyl, &#x2014;C(O)NH-alkylenyl-Rand &#x2014;C(O)NH; Ris a radical selected from the group consisting of O, NH, and S; and Ris N, O or S; and Ris selected from the group consisting of alkyl and alkylenyl-Rand Ris alkylenyl-R, wherein Ris selected from the group consisting of &#x2014;OH, &#x2014;OTs, halogen, spiperone, spiperone ketal, and spiperone-3-yl, or Rand Rtogether form a heterocyclic ring, optionally substituted with at least one radical selected from the group consisting of alkyl, alkoxy, OH, OTs, halogen, alkyl-R, carbonyl, spiperone, spiperone ketal and spiperone-3-yl, and further wherein one or more of the hydrogen, halogen or carbon atoms are optionally replaced with a radiolabel.

Compositions for labeling &#x3b2;-amyloid plaques and neurofibrillary tangles

Methods for labeling &bgr;-amyloid plaques and neurofibrillary tangles

A method for labeling &bgr;-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I):

Growing community of inventors

Santa Monica, CA, United States of America

Gregory M Cole