Massachusetts Institute of Technology

Harvard College

Northwestern University

University System of Maryland

Gregory Lee Szeto

Darrell J Irvine

Robert Samuel Langer

Klavs F Jensen

Ulrich Von Andrian

Pamela A Basto

Armon R Sharei

Evan A Scott

Joel Voldman

Siddharth Jhunjhunwala

John Christopher Love

Shirley Mao

George Hartoularos

Sophia Liu

Megan Heimann

Marilyn Allen

Nicholas B Karabin

Amit Golding

Marc Castellarnau

The present invention provides for delivery of therapeutic drug in a polymeric delivery system comprising a PEG-bl-PPS di-block polymer formed in a micelle, filomicelle, or polymersome structure, wherein the structure effectively binds and/or interacts through shape-based targeting with a targeted cell type.

Self-assembled particles for targeted delivery of immunomodulators to treat autoimmunity and cancer

A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.

Delivery of biomolecules to immune cells

A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtiter plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.

Method and apparatus for tracking cell identity

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Cambridge, MA, United States of America

Gregory Lee Szeto