Merck + Co., Inc.

Gregory L Helms

Otto D Hensens

Deborah L Zink

Robert A Giacobbe

Anne W Dombrowski

Dan A Ostlind

John G Ondeyka

Jon D Polishook

E Tracy Jones

Richard G Endris

Jerrold M Liesch

Gerald F Bills

Robert T Goegelman

Janet C Onishi

Robert E Schwartz

Fernando Pelaez

Maria T Diez

Suzanne M Mandala

David L Linemeyer

Guy H Harris

Isabel Martin

Francisca Vicente

Yu L Kong

Wendy S Horn

Walter Rozdilsky

Angeles Cabello

E Tracy Turner Jones

Ruth S Sykes

Julian Gorrochategui

Barnali Pramanik

Elvira Munguira

Maria T Diez Matas

There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.

Antiparasitic agents

A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.

Antifungal compound and compositions containing the compound

There is disclosed a series of macrolides isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.

Anthelmintic milbemycin analogs of novel microorganisms

Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.

Antibiotic agents

This invention relates to compounds of structural formula (I) ##STR1## which are useful as Cholestrol lowering agents.

Cholesterol lowering agents

Growing community of inventors

Fanwood, NJ, United States of America

Gregory L Helms