Biological Mimetics, Inc.

The United States of America As Represented by the Department of Health

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Lantern Pharma Inc.

Gregory J Tobin

Peter L Nara

George Lin

Shawn T Blumberg

Michael J Daly

Matthew A Gonda

Andrey D Malakhov

Varsin A Archer

Compositions useful as poliovirus immunogens are provided along with methods and compositions for preparing the same. Compositions comprising poliovirus immunogens can enable a host response that includes virus-neutralizing antibodies which can protect the host from infection and/or disease.

Irradiation-inactivated poliovirus, compositions including the same, and methods of preparation

This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.

Illudin analogs, uses thereof, and methods for synthesizing the same

Methods for providing novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host. The novel immunogens can be used as vaccines or to develop antibodies.

Immunogenic influenza composition

Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

Novel compositions useful as human rhinovirus immunogens are provided. The compositions enable a host response to sites normally not recognized by a host.

Immunogenic human rhinovirus (HRV) compositions

The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion partner, wherein the fusion partner is present in a Gag-fs-fusion partner fusion protein; an immunogenic composition comprising a pseudovirion; a Gag-fs-fusion partner fusion protein; and a method of making the pseudovirions of the present invention.

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Frederick, MD, United States of America

Gregory J Tobin