3M Innovative Properties Company

Graceway Pharmaceuticals, LLC

Gregory J Marszalek

Kyle J Lindstrom

Bryon A Merrill

John F Gerster

Michael J Rice

John W Mickelson

Philip D Heppner

Stephen L Crooks

Peter V Maye

Tushar A Kshirsagar

Scott E Langer

Gregory D Lundquist, Jr

Karl J Manske

Larry R Krepski

George W Griesgraber

William M Lamanna

Joseph F Dellaria, Jr

Shri Niwas

Michael E Danielson

Joshua R Wurst

Christopher K Haas

Sarah J Slania

Paul F Jaeger

Krystal Garringer

Sarah C Slania

Laser engravable films are disclosed. In one aspect, the laser engravable film of the present invention includes a monolayer film, preferably comprising polycarbonate, having a laser engraving additive and an antistatic composition mixed within the layer of polycarbonate. In another aspect, the laser engravable film of the present invention includes a first layer, preferably comprising polycarbonate, having an antistatic composition mixed within the first layer, and a second layer, preferably comprising polycarbonate, with laser engraving additives mixed within the second layer.

Static dissipating laser engravable film

A method of preferentially inducing IFN-&#x3b1; biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-&#x3b1; biosynthesis in an animal are disclosed.

Method of preferentially inducing the biosynthesis of interferon

Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines

Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-&#x3b1; biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Hydroxyalkyl substituted imidazoquinolines

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

Intermediates for imidazonaphthyridines

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Imidazonaphthyridines

Thiazolo-, oxazolo- and selenazolo&lsqb;4,5-c&rsqb;quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

Oxazolo, thiazolo and selenazolo &lsqb;4,5-C&rsqb;-quinolin-4-amines and analogs thereof

Oxazolo, thiazolo and selenazolo &lsqb;4,5-c&rsqb;-quinolin-4-amines and analogs thereof

Growing community of inventors

Saint Paul, MN, United States of America

Gregory J Marszalek