Centre National De La Recherche Scientifique

Macopharma, S.a.s.

Maco Pharma Societe Anonyme

Macopharma

Gregory Henard

Emilie Bessy

Christophe Hupin

Sonia Dakhli

Laurent Fouchet

Laurent Ducoroy

Pascal Marmey

Pierre Lutz

A filtration unit to selectively remove leukocytes from fluids containing platelets and systems including a filtration unit are provided. In one embodiment, a filtration unit is provided including an outer casing enclosing a porous element which includes a leukocyte-removal medium with a coating. The coating includes a polymer containing a main hydrophobic chain and a hydrophilic poly(ethylene oxide) side chain and having a mass average molar mass in the range of from about 1,000 g/mol to about 20,000 g/mol. The hydrophilic poly(ethylene oxide) side chain includes from 9 to 50 ethylene oxide units, and the mass percentage of the poly(ethylene oxide) side chain is less than about 50% of the mass average molar mass of the polymer.

Leukocyte filtration unit with reduced platelet adhesion

A method for grafting a porous element for leucodepletion by adsorption and/or filtration of a biological fluid, such as blood or a blood component, which method comprises the steps of impregnating the porous element with a solution containing a poly(ethylene oxide) having identical or different functional end groups; and applying an ionizing treatment to the impregnated porous element so as to ensure covalent cross-linking between the poly(ethylene oxide) and the porous element.

Method for grafting a porous element for leucodepletion

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Lille, France

Gregory Henard