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Sunnybrook and Women's College and Health Science Centre

Gregory Hannigan

John G Coles

Huanzhang Lu

Shoukat Dedhar

Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infraction (MI) remodeling comprising illiciting an overexpression of ILK, is described. The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal.

Upregulation of integrin linked kinase (ILK) to provide cardioprotective effects

Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described. The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal.

Modulation of the integrin linked kinase signaling pathway to promote cardiac cell proliferation and self-renewal

ILK genetic sequences and methods of use are provided. In some embodiments, a fragment or portion of an ILK polynucleotide is provided, where the polynucleotide has a sequence consisting of contiguous nucleotides within the provided ILK sequences, which may be within the provided ILK coding sequences. Such polynucleotides may be DNA, RNA, and the like, and may be double stranded or single stranded.

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Toronto, Canada

Gregory Hannigan