University of California

Gregory Grover

Heather D Maynard

Tatiana Segura

Karen L Christman

Masaki Fujita

Jonathan Lam

Michael Madani

Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.

Oxime cross-linked biocompatible polymer hydrogels and methods of use thereof

A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.

Method of creating hydrogels through oxime bond formation

Growing community of inventors

Carlsbad, CA, United States of America

Gregory Grover