Dakota Technologies, Inc.

Ndsu-Research Foundation

Gregory Gillispie

Mark Pavicic

Jimmie A Burt

Apparatus and methods are provided for rapid and sensitive quantitative analysis of a sample's fluorescence decay properties. A repetitively pulsed excitation light source generates pulsed fluorescence in the sample. A fluorescence wavelength selector receives a portion of the pulsed fluorescence emanating from the sample and outputs fluorescence photons whose wavelengths lie within a specified wavelength range. A photodetector receives the fluorescence photons within the specified wavelength range as an input from the fluorescence wavelength selector and outputs a time-dependent electrical signal. An array of memory elements stores a representation of the time-dependent electrical signal as a time-series of analog voltages or charges. Successive elements in the array correspond to a time increment of no greater than 4 ns. An analog-to-digital converter transforms the time-series of analog voltages or charges into a corresponding digitized fluorescence waveform.

Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures

A spectroscopic system that processes spatially dispersed electromagnetic emissions at a number of wavelengths from a test material. The spectroscopic system includes a converter that generates an electrical signal that is proportional to the intensity of electromagnetic radiation received by the converter. An optical delay circuit is coupled to an input of the converter. The optical delay circuit selectively delays application to the converter of electromagnetic emissions from the test material for at least one wavelength of electromagnetic emissions. A data processing circuit is coupled to an output of the converter. The data processing circuit records the value of the electrical signal from the converter over time so as to measure, contemporaneously, the intensity of electromagnetic emissions at each wavelength as a function of time.

Growing community of inventors

Fargo, ND, United States of America

Gregory Gillispie