Transonic Systems, Inc.

Gregory Galyanov

Nikolai M Krivitski

Cornelis J Drost

A system and method for identifying a disruption of a flow from an extracorporeal circuit to a patient circulatory system, such as a venous needle dislodgement or an access-bloodline separation, is based on flow rate data of the extracorporeal circuit. A patient contribution to the flow rate data can be identified as a harmonic and monitored to assess the presence of the disruption. The system can identify an inharmonic change, such as a spike, in the flow rate in the extracorporeal circuit, wherein the inharmonic change can be used alone or in conjunction with the identified harmonic to assess the existence of the disruption. The system can employ the spike in a blood flow rate as well as a spike in a dialysate flow rate fluidly connected to the extracorporeal circuit, wherein the spike can be used to identify the disruption.

Method and apparatus for identifying disruption of a fluid connection between an extracorporeal circuit and a patient circulatory system

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit includes determining the cardiac output corresponding to a blood flow rate through an extracorporeal blood oxygenation circuit, a first arterial carbon dioxide content or surrogate, a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to a first removal rate of carbon dioxide from the blood; a second arterial carbon dioxide content or surrogate and a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to a second removal rate of carbon dioxide from the blood.

Calculating cardiac output of a patient undergoing veno-venous extracorporeal blood oxygenation

A system for calculating cardiac output (CO) of a patient undergoing veno-arterial extracorporeal oxygenation includes measuring first oxygenated blood flow rate by a pump in the extracorporeal blood oxygenation circuit as introduced into an arterial portion of the patient circulation system and a corresponding arterial oxygen saturation, then changing the pump flow rate, such as decreasing, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances, operating errors or drift), which change in the arterial oxygen saturation is measured. From the first flow rate and the second flow rate along with the corresponding measured arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation. Alternatively, the CO of the patient can be calculated, without reliance upon a change in flow rate by changing a gas exchange with the blood in the extracorporeal blood oxygenation circuit to impart corresponding changes in a blood parameter in the arterial portion of the patient circulation system and the blood delivered from the extracorporeal blood oxygenation circuit.

Method and apparatus for assessing cardiac output in veno-arterial extracorporeal blood oxygenation

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit includes measuring first oxygenated blood flow rate by a pump in the extracorporeal circuit and a corresponding arterial oxygen saturation and recirculation in the extracorporeal circuit, then changing the pump flow rate, such as decreased, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances or drift), which change in the arterial oxygen saturation and recirculation are measured. From the first flow rate and the second flow rate along with the corresponding measured recirculation and the arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation. The system also includes an accommodation of oxygenation by the lungs of the patient during the extracorporeal blood oxygenation.

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Ithaca, NY, United States of America

Gregory Galyanov