Mcneil-ppc, Inc.

Johnson & Johnson Consumer Inc.

Mcneil Ab

Nicklasson, Fredrik

Gregory E Koll

Gerard P McNally

Christopher Szymczak

Leo B Kriksunov

Harry S Sowden

Frank J Bunick

Jen-Chi Chen

Vipul Bhupendra Dave

Joseph R Luber

Seema Mody

Kristina Thyresson

Katarina Lindell

Oliver Anderson

Stephen Ulrich

Jill Nilgard

Gerard McNally

Roland Olsson

David B Cochran

Christopher E Szymczak

Andreas Hugerth

Fredrik Nicklasson

John Hendenstrom

Gerard Mcnally

Gerard P Mcnally

Rolland Olsson

The invention relates to a soft chewable dosage form comprising a first active pharmaceutical ingredient encapsulated in a lipid material that is embedded in the soft chewable dosage form and wherein the soft chewable dosage form comprises at least a second active pharmaceutical ingredient as well as a method of treating a subject suffering from a disease or disorder in the gastro intestinal tract using the soft chewable dosage form.

Soft chewable dosage form

The invention relates to a chewing gum comprising at least a gum core comprising nicotine polacrilex, at least a one outer coating covering the core, comprising at least one sugar alcohol or mixtures of sugar alcohols and, at least a one portion fused onto the outer coating, wherein the portion comprises nicotine bitartrate or nicotine ditartrate dihydrate and at least one sugar alcohol or a mixture of sugar alcohols and at least one buffer present in the coating and/or in a portion fused to the coating.

Chewing gum comprising nicotine

The present invention relates to a lozenge dosage form having a disintegrative tablet portion and a candy glass shell portion.

Lozenge dosage form having a disintegrative tablet portion and a candy glass shell portion

In one aspect the present invention features a process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate.

Process for making tablet using radiofrequency and lossy coated particles

In one aspect the present invention features process for making a tablet comprising at least one pharmaceutically active agent, said method comprising the step of applying radiofrequency energy to a powder blend to sinter said powder blend into said tablet, wherein said powder blend comprises lossy coated particles and said at least one pharmaceutically active agent, wherein said lossy coated particles comprises a substrate that is at least partially coated with a lossy coating comprising at least one activator, wherein said substrate has a Q value of greater than 100 and said activator has a Q value of less than 75.

The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.

Manufacture of lozenge product with radiofrequency

The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radiofrequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.

Manufacture of chewing gum product with radiofrequency

A chewing gum comprising at least one active pharmaceutical ingredient (API) with a core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent(s) and result in the domination of flavoring agents in the coating(s) over flavoring agent(s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent(s) in the coating(s) and (b) achieving an increased control of the release of the API and of non-active excipients.

Flavoring of drug-containing chewing gums

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Hillsborough, NJ, United States of America

Gregory E Koll