Entremed, Inc.

Miikana Therapeutics, Inc.

Gregory E Agoston

Anthony Treston

Jamshed H Shah

Theresa Marie LaVallee

Victor S Pribluda

John S Ward

Xiao-Yi Xiao

Shawn J Green

Mark R Bray

Dinish V Patel

Lita Suwandi

Kimberly A Hunsucker

Christopher J Herbstritt

Xiaoguo H Zhan

Anthony M Treston

Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ris selected from &#x2014;OCH, &#x2014;OCHCHor &#x2014;CCCH; and Z is selected from &#x3e;C(H)&#x2014;OH, &#x3e;C(H)&#x2014;O-alkyl, &#x3e;C(H)&#x2014;O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.

Methods of treating disease states using antiangiogenic agents

Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

Method of treating disease states using substituted pyrazole compounds

Substituted pyrazole compounds

Antiangiogenic agents

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.

Estradiol derivatives and pharmaceutical compositions using same

2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.

Methods of using 2-methoxyestradiol of high purity

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.

Compositions comprising purified 2-methoxyestradiol and methods of producing same

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula:wherein the variables are defined in the specification.

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Germantown, MD, United States of America

Gregory E Agoston