Medispectra, Incorporated

Gregory DeBaryshe

Mark D Modell

A Ze'ev Hed

An optical probe collects light emanating from a specimen that selectively andpreferentially represents a localized volume element within the sample, with illuminationintensity and collection efficacy both dropping off away from the localized volume element to limit the integrated contribution from outside the element. For example, the optics provide high peak illumination and high collection efficiency which both overlap in volume elements of a limited size corresponding to a structure or process of the specimen. The resulting collected signal comprising one or more spectral segments is highly correlated with optical characteristics, such as absorbance, scattering or fluorescence characteristics of material in the small volume elements. A processor may apply a previously-derived vector or matrix transform to the collected responses to produce an output. The collected spectra or other responses have high signal strength and represent small or otherwise inaccessible or masked optical effects present in the sample, so that they are readily correlated to conditions of interest.

Spectral volume microprobe for analysis of materials

An optical probe collects light responses from a specimen that selectively and preferentially emanates from a localized volume element within the sample, with illumination irradiance and collection efficiency both dropping off away from the localized volume element, and a processor applies a vector or matrix transform to collected responses to produce an output. The optics provide high peak illumination and high collection efficiency which both overlap in small volume elements that are limited in length, width or depth to correspond to a structure or process of the specimen so that the collected spectra or other responses have high signal strength and enhanced correlation values to small or otherwise inaccessible or masked effects present in macroscopic or submacroscopic regions. Responses from volumes outside the localized element are substantially rejected and correlation transforms are readily derived from the strong spectral responses of tissue samples having an independently identified pathology or condition and these transforms are stored. A processor then applies the stored transforms so obtained to a newly collected response to determine the presence or extent of a particular pathology in the observed tissue.

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Lincoln, MA, United States of America

Gregory DeBaryshe