Wisconsin Alumni Research Foundation

Gregory Dean Kennedy

Michael Richard Sussman

William M Sugden

William Franklin Dove

Mark Reichelderfer

Perry Joseph Pickhardt

Melanie Mae Ivancic

Amy Ann Irving

Adrian Daniel Hegeman

Jindong Wang

Jennifer Kathleen Pleiman

Atsushi Jun Komano

Edward Lee Huttlin

Xiaodi Chen

This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Methods for detection, staging, and surveillance of colorectal adenomas and carcinomas

This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Methods for detection and treatment of colorectal cancer

The invention provides a vector encoding a derivative of EBNA-1 that is not cytotoxic when expressed efficiently in cells, which supports extrachromosomal replication, maintenance and transcription from extrachromosomal oriP containing vectors but does not substantially activate transcription from host cell genes. Also provided is a vector having oriP and encoding a derivative of EBNA-1. The vectors of the invention may be employed in vitro and in gene therapy.

Non-cytotoxic oriP replicon

A method of assaying potential inhibitors of EBNA-1 is disclosed. In one aspect, this invention comprises the steps of (a) obtaining an EBV-positive cell line and an EBV-negative cell line; (b) exposing the cell lines to a test compound, and (c) observing the effect of the compound on induction of apoptosis in the cell lines, wherein significant apoptosis in the EBV-positive cell line and lack of significant apoptosis in the EBV-negative cell line indicates a compound that specifically inhibits EBNA-1.

Method of identifying inhibitors of EBNA-1

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Madison, WI, United States of America

Gregory Dean Kennedy