Merck + Co., Inc.

Gregory D Berger

Joel Peter Berger

David E Moller

Mark D Leibowitz

Arthur A Patchett

Richard B Toupence

Conrad Santini

James D Bergstrom

Robert M Burk

Richard L Tolman

Tesfaye Biftu

William H Parsons

Soumya P Sahoo

Mitree M Ponpipom

Alan D Adams

Robert L Bugianesi

Narindar N Girotra

Thomas W Doebber

Robert W Marquis, Jr

Lori L Whiting

John T Olson

Thomas F Walsh

Byron H Arison

Donald W Graham

Leeyuan Huang

Derek J Von Langen

John J Acton, Iii

Kenneth J Fitch

Yuan-Ching P Chiang

Edward M Scolnick

Jeffrey P Bergman

Claude Dufresne

John G MacConnell

Chan-Hwa Kuo

Alfred W Alberts

Wei Han

Albert J Robichaud

Anthony B Jones

C H Kuo

Sandra P Plevyak

Jonthan R Young

The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.

Benzisoxazole-derived antidiabetic compounds

Method of treating diabetes and related disease states

Antidiabetic agents

Cholesterol lowering compounds

This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.

Cholesterol-lowering agents

New cholesterol lowering compounds are formed from the photochemical treatment of zaragozic acid A.

Chemical compounds

Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.

Compounds of structural formula (I): ##STR1## are squalene synthestase inhibitors useful in inhibiting the biosynthesis of cholesterol in the treatment of hypercholesterolemia and related disorders.

Squalene synthetase inhibitors

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Stonington, CT, United States of America

Gregory D Berger