Pds Biotechnology Corporation

Gregory Conn

Leaf Huang

Frank Bedu-Addo

Elizabeth Ann Vasievich

Kenya N Toney Johnson

Weihsu Claire Chen

Weihsu Chen

Weili Yan

Kenya Toney

A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in Ris a quaternary ammonium group, Yis a space chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, Rand Rare independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combination thereof.

Stimulation of an immune response by enantiomers of cationic lipids

A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in Ris a quaternary ammonium group, Yis a spacer chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, Rand Rare independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combinations thereof.

Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.

The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.

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Lawrenceburg, IN, United States of America

Gregory Conn