Chiesi Farmaceutici S.p.a.

Other

The Medicines Company

Gregory Charles Williams

Rajeshwar Motheram

Patrick J Sinko

Stanley Stein

Tamara Minko

Xiaoping Zhang

Bo Qiu

Michael Leibowitz

Edward C Spindler, Jr

Ming-yi Hu

Srinivasan Ramanathan

Goubao Zhang

Shahrair Pooyan

Seong Hee Park

Loretta M Itri

Pankaj Paranjpe

Ming-Yi Hu

Edward Spindler

Jr Spindler Edward C

Pharmaceutical formulations comprising clevidipine in an oil-in-water formulation that is resistant to microbial growth and stable against the formation of impurities.

Clevidipine emulsion formulations containing antimicrobial agents

Methods for controlling, maintaining, or reducing blood pressure, and/or for treating, preventing, or alleviating symptoms such as dyspnea, in a patient suffering from or susceptible to acute heart failure. The methods involve the administration of an effective amount of a pharmaceutical composition comprising a short acting dihydropyridine compound such as clevidipine. The pharmaceutical composition may be administered at an initial dose, and if blood pressure is not controlled or maintained within a target blood pressure range or reduced to within a target blood pressure range, the initial dose may be titrated to achieve a blood pressure within the target blood pressure range. The patient may have a systolic blood pressure of about 120 mmHg or above.

Methods for controlling blood pressure and reducing dyspnea in heart failure

Pharmaceutical formulations comprising clevidipine and an antimicrobial agent exhibit a reduced propensity for microbial growth and provide increased convenience to health care workers administering clevidipine-containing formulations to patients.

The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents

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Bernardsville, NJ, United States of America

Gregory Charles Williams