Akzo Nobel N.v.

Akzo N.v.

Gregory Alan Hawkins

Reinhard Bredehorst

Nicholas Pomato

Carl-Wilhelm Ernst Vogel

Richard P McCabe

Chong-Ho Kim

A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.

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Hastings, NE, United States of America

Gregory Alan Hawkins