Cordis Corporation

Wyeth

Cordis Corportation

Cardinal Health Switzerland 515 Gmbh

Gerard H. Llanos

Robert Falotico

Gregory a. Kopia

John Siekierka

Andrew J. Carter

Gregory A Kopia

Gerard H Llanos

Andrew James Carter

John J Siekierka

Pallassana V Narayanan

George Landau

George Papandreou

Gerald H Llanos

Andrew J Carter

A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.

Drug/drug delivery systems for the prevention and treatment of vascular disease

The current invention comprises an approach to solving the clinical problem of restenosis, which involves the administration of combinations of drugs to patients undergoing PTCA or stent implantation. In one embodiment of the invention, an antiproliferative agent such as rapamycin, vincristine or taxol is administered in combination with the antiinflammatory agent, dexamethasone, to patients systemically, either subcutaneously or intravenously. In another embodiment of the invention, the antiproliferative and antiinflammatory agents are bound in a single formulation to the surface of a stent by means of incorporation within either a biodegradable or biostable polymeric coating. Alternatively, such drug combinations could be incorporated into a stent constructed with a grooved reservoir.

Drug combination useful for prevention of restenosis

Antiinflammatory drug and delivery device

Growing community of inventors

Hillsborough, NJ, United States of America

Gregory A Kopia