Lubrizol Advanced Materials, Inc.

Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.

Lipotec, S.a.

Lipotrue, S.l.

Gregorio Fernández Ballester

Antonio Vicente Ferrer Montiel

Giorgina Mangano

Cristina Carreño Serraïma

Juan Cebrián Puche

Wim Van Den Nest

Nuria Almiñana Domenech

Raquel Delgado González

José María García Antón

Núria Almiñana Doménech

Francesca Mancini

Antonio Ferrer Montiel

Juan Carlos Escudero

Ariadna Grau-Campistany

Isabel Devesa Giner

Patricia Carulla

Cristina Bartella

Julia A Boras

Cristina Carreño Serrïma

Pastor Silvia

Nuria GARCÍA Sanz

Núria ALMIÑANA DOMÉNECH

Cristina CARREÑO SERRAÏMA

Raquel Delgado GONZÁLEZ

Núria ALMIÑANA Domenech

José Maria García Anton

The invention relates to peptides capable of inhibiting neuronal exocytosis and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions, disorders and/or diseases mediated by neuronal exocytosis, such as wrinkles, excessive perspiration, pruritus, cutaneous inflammation, dermatitis, atopia, psoriasis, vascular hyperreactivity, rosacea, acne, hair growth, wound healing, calluses, warts, or sensitive skin conditions, such as ulcers and lesions on the skin.

Peptides for inhibiting cholinergic calcitonin gene-related peptide (CGRP) and acetylcholine (ACH) release or inhibiting sensitization-mediated by TRPV1-mediated excitability in sensory neurons and methods of use thereof

Peptides able to inhibit the muscarinic receptor M3 activity and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions mediated by the muscarinic receptor M3 activity, such as excessive perspiration, inflammation, sebum production, and cell adhesion, motility, growth, differentiation and proliferation.

Peptides having inhibitory activity on muscarinic receptor M3

Compounds of general formula (I): R&#x2014;W&#x2014;X-AA-AA-AA-AA-AA-AA-AA-Y&#x2014;Z&#x2014;R, their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

Compounds which inhibit neuronal exocytosis

Compounds of general formula (I): R-W-X-AA-AA-AA-AA-AA-AA-AA-AA-AA-Y-Z-R(I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

Compounds of general formula (I): R-W-X-AA-AA-AA-AA-AA-AA-Y-Z-R(I) their stereoisomers, mixtures thereof, their cosmetically or pharmaceutically acceptable salts and/or its functionally equivalent variants, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

Peptide compounds that inhibit neuronal exocytosis

Growing community of inventors

Murcia, Spain

Gregorio Fernández Ballester