Roche Diagnostics Operations, Inc.

Roche Diabetes Care, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Gregor Ocvirk

Carlo S Effenhauser

Helmut Rinne

Christoph Boehm

Sascha Lutz

Arnulf Staib

Karl-Heinz Koelker

Claudia Gaessler-Dietsche

Heinz Kontschieder

Peter Kraemer

Wolfgang Fiedler

Karl-Heinz Kölker

Miriam Ruf

Wolfgang Burkhardt

Alexander Steck

Angelika Fuerst

Juergen Woehrle

The present disclosure relates to an electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules.

Diffusion layer for an enzymatic in-vivo sensor

The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

Sensor assembly

The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.

Enzyme stabilization in electrochemical sensors

The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, between an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.

Method and fuel cell for electrochemical measurement of analyte concentration in vivo

The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, beween an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.

The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.

Analyte monitoring sensor system for monitoring a constituent in body tissue

Sensor system as well as an arrangement and method for monitoring a constituent and in particular glucose in body tissue

The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

Method for monitoring an arrangement for determining the concentration of an analyte in a body fluid

The invention relates to a test element for the testing of a liquid sample. The test element includes a sample application area, a test field, a sample transport path extending between the sample application area and the test field and an actuator field including an electrically-conductive layer. The actuator field is switchable between a first state attracting the sample and a second state attracting the sample less by applying to the conductive layer an electric voltage that is different from an earth potential. The actuator field has a section that is arranged at about the same distance from the sample application area as the test field, measured along the sample transport path. Such that, a wetting of the test field by the sample can be controlled by applying a voltage to the actuator field.

Test element, system, and method of controlling the wetting of same

The invention concerns a device which is used to separate gas or liquid from microfluidic flow-through systems. The gas or liquid separation is achieved independently of the spatial orientation of the device. In addition the invention concerns a microfluidic flow-through system in which a device according to the invention enables bubble-free fluid transport.

Device for extracting gas or liquid from microfluidid through-flow systems

A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.

Method and separating module for the separation of particles from a dispersion, in particular of blood corpuscles from blood

The invention relates to the technical field of microfluidic channel structures. The invention discloses a microfluidic channel system with a high aspect ratio as well as a process for producing the microfluidic system. The process according to the invention enables the production of channel structures with aspect ratios of any magnitude without the process being limited by the manufacturing conditions to certain materials for the channel system. The channel system can thus be optimally adapted to a desired field of application.

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Mannheim, Germany

Gregor Ocvirk