Vanderbilt University

Gregor McDonald

Craig William Lindsley

P Jeffrey Conn

Shaun R Stauffer

José Manuel Bartolome-Nebreda

Carrie K Jones

Susana Conde-Ceide

Han Min Tong

Ya Zhou

Jason Manka

In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators

In one aspect, the invention relates to substituted pyrazolo[1,5-a]pyrazine compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors

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Beerse, Belgium

Gregor McDonald