Schering Aktiengesellschaft

Gregor Haffer

Gerhard Sauer

Ulrich Eder

Rudolf Wiechert

Jurgen Ruppert

Gunter Neef

Klaus Nickisch

Helmut Borner

Helmut Hauser

Juergen Ruppert

Andreas Huth

Helmut Wachtel

Herbert H Schneider

Helmut Biere

Alfred Weber

Mario Kennecke

Wolfgang Kubler

Henry Laurent

Yukishige Nishino

Wolfgang Kehr

Guenter Neef

Hermann Steinbeck

Julius Deutsch

Rudolf Muller

Hans Peter Lorenz

Reiner Wierzchowski

Heidi Hummel-Maquardt

Alfred Popper

Process for the production of b-carbolines

Process for the production of indole derivatives

Process for the production of ergoline derivatives

Disclosed is chemoselective phenylation of 5-hydroxy-.beta.-carbolines in the presence of weak bases while adding water.

Selective phenylation of 5-hydroxy-.beta.-carboline derivatives

Process for the production of gramine derivatives

2-bromo-8-ergolinyl compounds of the formula ##STR1## wherein R.sup.8 is NH.sub.2, NH--CONEt.sub.2, CONH.sub.2, ##STR2## and ##STR3## wherein R.sup.1 =C.sub.1-4 -alkyl and

Process for the preparation of 2-bromo-8-ergolinyl compounds

Ergoline derivatives of general Formula I ##STR1## wherein C.sub.8  C.sub.9 and C.sub.9  C.sub.10 are both CC-single bonds or one is a C.dbd.C-double bond,

Process for the production ergoline derivatives

Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) ##STR1## and physiologically compatible salts thereof, wherein (a) R.sup.1 is hydrogen, the 8-substituent can be in the .alpha.- or .beta.-position and ##STR2## represents a single or a double bond, R.sup.2 is hydrogen, C.sub.1-4 -alkyl or C.sub.1-7 -acyl,

Novel ergolinyl compounds nitrogen-substituted in the 8-position, useful

Ergolinylthioureas derivatives of the general Formula I ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or acyl,

Process for the preparation of ergolinylthioureas

Substituted ergolines of the formula ##STR1## and their acid addition salts, wherein the urea side chain in the 8-position can be in the d.alpha.- or .beta.-configuration, C.sub.2 C.sub.3 and C.sub.9  C.sub.10 are a CC single or C.dbd.C double bond, and

Optionally 11- to 13-substituted ergoline compounds useful as medicinal

A process for preparing an ergoline of the formula ##STR1## wherein C.sub.9 ----C.sub.10 is a CC single or double bond,

Process for the preparation of ergoline derivatives

2-bromoergolines can be reduced in good yields, without dimerization as determined by NMR product analysis, to the corresponding 2,3-dihydroergolines under otherwise conventional reducing conditions by introducing 2-bromoergolines, together with sodium borohydride, into trifluoroacetic acid under cooling to prevent the reaction mixture from rising above ambient temperature.

Process for the production of 2,3-dihydroergolines

.beta.-carbolines of formula I ##STR1## wherein R=C.sub.1-5 alkyl

Process for the production of .beta.-carbolines by dehydrogenation

A process for preparing lysergic acid esters of the formula ##STR1## wherein R is alkyl of up to 3 carbon atoms, comprises reacting corresponding lysergic acid or isolysergic acid amides with corresponding alcohols at temperatures of 0.degree. to 65.degree. C. for 2 to 30 hours in the presence of an acid at a pH value of 0-1.

Process for the preparation of lysergic acid esters

16 .alpha.-Alkyl steroids of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,

16 .alpha.-Alkyl steroids, their preparation, and pharmaceutical

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Berlin, Germany

Gregor Haffer