Basf Aktiengesellschaft

Evonik Degussa Gmbh

Basf Se Corporation

Paik Kwang Industrial Co., Ltd.

Basf Aktiencesellschaft

Gregor Haberhauer

Oskar Zelder

Markus Pompejus

Hartwig Schröder

Burkhard Kröger

Corinna Klopprogge

Stefan Haefner

Hartwig Schr&ouml;der

Corrinna Klopprogge

Burkhard Kr&ouml;ger

Hyung-Joon Kim

Jun-Won Kim

Heung-Shick Lee

Uwe Ruffer

Byung-Joon Hwang

Heung Shick-Lee

Claudia Isabella Graef

Hartwig SCHRÖDER

Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins fromare described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis

Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins fromare described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

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The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.

Gene variants coding for proteins from the metabolic pathway of fine chemicals

Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins fromare described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound frombased on genetic engineering of MP genes in this organism.

Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins fromare described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound frombased on genetic engineering of PTS genes in this organism.

Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins fromare described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound frombased on genetic engineering of SMP genes in this organism.

The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

Genes coding for metabolic pathway proteins

The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of the genetically improved microorganisms.

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Limburgerhof, Germany

Gregor Haberhauer