Roche Diagnostics Operations, Inc.

Boehringer Mannheim Gmbh

Roche Diabetes Care, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Gregor Bainczyk

Michael Marquant

Herbert Wieder

Manfred Augstein

Stefan Riebel

Bruno Robert Thoes

Holger Kotzan

Oliver Kube

Bernd Roesicke

Rolf Lerch

Stefan Lindegger

Otto Gaa

Michael Schoemaker

Joerg Scherer

Dieter Meinecke

Karin Schwind

Sandro Niederhäuser

Andreas Menke

Martin Mueri

Karin Obermaier

Albert Grosser

Klaus-Dieter Sacherer

Hans Wielinger

Volker Unkrig

Rolf Nagel

Helmut Leininger

Mihail-Onoriu Lungu

Udo Zapf

Bruno Thös

Thomas Eisele

Jack Bush

Martin Müri

Jörg Scherer

The invention relates to an electrochemical sensor for the determination of a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid, to an apparatus that includes the electrochemical sensor, and to a use of the electrochemical sensor, and finally to a method for producing it. The electrochemical sensor has an isolation element and at least two electrodes. The at least two electrodes comprise at least one working electrode and at least one further electrode, in particular at least one counter electrode and/or at least one reference electrode. The at least two electrodes run parallel to one another and form an electrochemical measuring cell of the electrochemical sensor.

Electrochemical sensor for determining an analyte concentration

The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.

Method of compression data from in-vivo measurements of an analyte concentration in a human

Methods of producing an electrochemical sensor for determining an analyte concentration

An implantable sensor is provide which can be used for determining a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid. The implantable sensor has a layered construction with at least one insulating carrier substrate and at least two electrodes which are arranged in at least two different layer planes of the implantable sensor and are electrically isolated from one another by the at least one insulating carrier substrate. The electrodes have electrode areas which face the medium when the sensor has been implanted, and are in contact with the medium over a large area and substantially uniformly, directly or via a generally analyte-permeable membrane layer.

Layered sensor for determining an analyte concentration

Electrochemical sensor for the determination of an analyte concentration

System for in-vivo measurement of an analyte concentration

An analysis device for analysis of a sample on a test element is provided that comprises at least one component configured to make electrical contact with at least one other component for electrical transmission therebetween. The at least one component generally comprises an injection-molded circuit mount, also called an MID, or molded interconnect device.

Device for analysis of a sample on a test element

An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.

Electrical connection system for an electrochemical analysis system

An electrochemical biosensor analysis system is provided for analyzing a sample liquid, comprising a biosensor having an electrode structure made of at least two electrodes, a test field, covering the electrode structure and capable of absorbing the sample liquid, and a defined sample application surface on the top side of the test field. The system also includes an analysis instrument comprising an evaluation unit for determining the desired analysis data. The analysis instrument comprises an AC resistance measuring device for measuring an AC resistance value between two electrodes of the electrode structure by means of an area compensation measurement. The measured AC resistance value is used, in the determination of the analysis data, as a measure of the partial area of the effective electrode structure area wetted by the sample liquid.

Electrochemical biosensor analysis system

A test device for determining the concentration of at least one analyte in a sample using a element is proposed. The test device can be used particularly for glucose measurement, in particular blood glucose measurement, cholesterol measurement and/or coagulation measurement. The test device according to the invention comprises a housing with a closed state and an opened state, and a storage device for receiving at least one test element. The at least one test element is typically designed as a strip-shaped test element, and the storage device typically comprises a magazine. The magazine comprises a plurality of cavities, and the test elements are received substantially parallel to one another in the cavities. A measuring device and a dispensing device are also provided. The dispensing device comprises means for conveying the at least one test element from at least one storage position of the storage device during opening of the housing.

Test device for determining an analyte concentration

The invention relates to an electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system. The analysis system comprises an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and at least one electrical contact element configured to make electrical contact with at least one electrical contact surface of an analytical test element, and to produce an electrical connection between the contact surface and the evaluation appliance. The at least one contact element is arranged to move to contact the contact surface of a test element held either in a fixed test element holder or a moveable test element holder, such as a slide. Furthermore, the analysis system has a means for moving the electrical contact element to the electrical contact surface of an analytical test element when the test element holder is in the measurement position.

Electrical connection system for electrochemical analysis system

The invention concerns a system for the storage and transport of sample material on absorbent material which is characterized in that the system contains no test reagents and it additionally includes a closable container containing a medium that can absorb moisture such as a desiccant in addition to the absorbent material for absorbing a liquid sample. Furthermore the system according to the invention can contain an agent to stabilize the sample material and optionally further auxiliary substances.

Storage and transport system for sample material

The subject of the invention is an article for collecting and transporting a sample to be analyzed; containing an absorbent matrix to absorb a liquid sample, characterized in that the absorbent matrix represents the sample collecting area of a sample collecting element, which is an integral part of an envelope. In addition, the subject of the invention is a process for determining an analyte, in which liquid sample material is placed on an absorbent matrix, dried, sent to a laboratory and tested there, characterized in that the liquid sample material is placed on an absorbent matrix that represents the sample collecting area of a sample collecting element, which is an integral part of an envelope.

Article for collecting and transporting a sample to be analyzed

Growing community of inventors

Mannheim, Germany

Gregor Bainczyk