Ecole Polytechnique Federale De Lausanne

Onward Medical N.v.

Onward Medical B.v.

Ecole Polytechnique Féderale De Lausanne (Epfl)

Gtx Medical B.v.

Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto

G-Therapeutics Bv

Gregoire Courtine

Marco Capogrosso

Fabien Wagner

Vincent Delattre

Jurriaan Bakker

Robin Brouns

Karen Minassian

Bert Bakker

Andre Kleibeuker

Silvestro Micera

Edoardo Paoles

Jocelyne Bloch

Eduardo Martin Moraud

Damien Ganty

Tomislav Milekovic

Joachim Von Zitzewitz

Nikolaus Wenger

Robin Demesmaeker

Marco Bonizzato

Leonie Asboth

Henri Lorach

Jordan Squair

Janos Vörös

Miroslav Caban

Pavel Musienko

Sjaak Deckers

Nathan Greiner

Andreas Rowald

Flavio Raschella

Silvestro Misera

Jerome Gandar

Heike Vallery

Alexandre Larmagnac

André Kleibeuker

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includes

System for planning and/or providing neuromodulation

Lead paddle

The present disclosure provides devices, systems, and methods for spinal cord stimulation. In some exemplary embodiments, a lead is provided. In one exemplary embodiment, the lead includes a paddle and an electrode array distributed in the paddle. The electrode array includes a first column of electrodes and a second column of electrodes. The first column of electrodes and the second column of electrodes are symmetric about the midline of the paddle. The first column of electrodes includes a first electrode, a second electrode, and a third electrode. The second column of electrodes includes a fourth electrode corresponding to the first electrode, a fifth electrode corresponding to the second electrode, and a sixth electrode corresponding to the third electrode. A vertical inter-electrode distance between the first electrode and the second electrode is larger than that between the second electrode and the third electrode.

Devices and systems for electrical stimulation and methods of use

The present invention relates to an electrode array for neuromodulation, comprising a first electrode section with more than two electrodes being arranged parallel and densely packed in the first electrode section, further comprising a second electrode section with more electrodes than in the first electrode section, the electrodes in the second electrode section being arranged symmetrically with respect to the longitudinal axis and transversal offset to each other. Furthermore, the present invention relates to a lead paddle and a neuromodulation system.

Electrode array, a lead paddle and a neuromodulation system

The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes

The present invention relates to methods and systems for planning and/or providing neuromodulation. An example system comprises a neurostimulator comprising a least one electrode, functional mapping module configured and arranged such that based on stimulation related basic data and stimulation related response data and transfer data a digital characteristic functional map is generated and/or provided, which describes the interrelation between the stimulation related basic data and the stimulation related response data and the transfer data, andanalysis module configured and arranged such that the digital characteristic functional map may be analyzed in connection with neurostimulation provided by the neurostimulator such that the provided neurostimulation and its response may be analyzed on the basis of the functional map and that on the basis of this analysis a placement analysis of a placement of the electrode is provided.

System for planning and/or providing neuromodulation, especially neurostimulation

The present invention relates to systems and methods for planning and/or providing neurostimulation for a patient. An example system includes

System for planning and/or providing neurostimulation for a patient

The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

The present invention relates to a robotic system useful to unload an object/person from its weight. The robotic system is useful in locomotor rehabilitation programs and allows the manipulation of forces in a three-dimensional space with far lower actuator requirements and a much higher precision than prior-art systems. The apparatus combines passive and active elements to minimize actuation requirements while still keeping inertia to a minimum and control precision to a maximum. It requires minimal actuators and at the same time has a low inertia.

Apparatus to apply forces in a three-dimensional space

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.

Two-phase calibration of a neuroprosthetic system

An implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested. The device comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrate. Not only the substrate, but also the leads are stretchable. The substrate may consist of PDMS, and the leads may consist of a conductive PDMS, in particular, PDMS with an electrically conductive filler material, and may optionally be metal-coated. The device defines a multi-electrode array which may be employed for neurostimulation in the epidural or subdural space of an animal or human.

PDMS-based stretchable multi-electrode and chemotrode array for epidural and subdural neuronal recording, electrical stimulation and drug delivery

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

Apparatus and method for restoring voluntary control of locomotion in neuromotor impairments

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Lausanne, Switzerland

Gregoire Courtine