Synovis Orthopedic and Woundcare, Inc.

Regeneration Technologies, Inc.

Gregg Ritter

Thomas W Sander

Chandrasekaran Nataraj

John F Wironen

Russell S Donda

Chris Seid

Rebecca Jaw

Thien Doan

Bioimplants and methods of making the bioimplants are provided. The bioimplants comprise biological tissues having conjugated thereto adjunct molecules. The biological tissues are sterilized with a chemical sterilizing agent, such as a water soluble carbodiimide. The processes of making the bioimplants include a process in which an adjunct molecule is conjugated to a biological tissue during the sterilization process.

Stabilized, sterilized collagen scaffolds with active adjuncts attached

Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.

Processed soft tissue for topical or internal application

Growing community of inventors

Gainesville, FL, United States of America

Gregg Ritter