Gilead Sciences, Inc.

Gregg M Schwarzwalder

Lan Jiang

Michael L Mitchell

Ana Zurisadai Gonzalez Buenrostro

Xiaochun Han

Hong Yang

Jiayao Li

Qiaoyin Wu

Hang Chu

Hongyan Guo

Jennifer R Zhang

David W Lin

Anna E Hurtley

Devleena M Shivakumar

Matthew J Von Bargen

William John Watkins

Hyung-Jung Pyun

Chandrasekar Venkataramani

Peter A Blomgren

Scott D Schroeder

Devan Naduthambi

Musong Kim

Zhimin Du

Suet Chung Yeung

Julian Andrew Codelli

Nathan D Shapiro

Gayatri Balan

Rhiannon Thomas-Tran

Helen Yu

Suzanne M Szewczyk

Michael T Tudesco

Chen Chen

Ezra Roberts

Dorothée Saddier Axe

Brian M Weist

James G Taylor

Jamie Geier Bates

Ting Wang

Brian J Kirby

Yurong Lai

Ana Z Gonzalez Buenrostro

The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

IKAROS Zinc Finger Family degraders and uses thereof

Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R, L, W, W, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use

The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Substituted pyridotriazine compounds and uses thereof

The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Tetracyclic compounds and uses thereof

The present disclosure relates generally to compounds, of Formula I Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Bridged tricyclic carbamoylpyridone compounds and uses thereof

The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

IKAROS zinc finger family degraders and uses thereof

The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Thienopyrimidine derivatives as ACC inhibitors and uses thereof

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Redwood City, CA, United States of America

Gregg M Schwarzwalder