Abbott Laboratories Corporation

Gregg E Robinson

Ashok V Bhatia

Xiu Chun Wang

David A Riley

Steven A Chamberlin

John J Hufnagel

Steve A Chamberlin

A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

Processes for the preparation of D-chiro-inositol

Provided is a novel process for the preparation of iohexol having improved yields and purity, reduced number of isolated intermediates, and significantly reduced volume of ion-exchange resins required to desalinate the final product.

Process for the preparation of iohexol

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Skokie, IL, United States of America

Gregg E Robinson