Circuit Therapeutics, Inc.

Greg Stahler

Karl A Deisseroth

Dan E Andersen

David F Moore

David G Angeley

David Charles Lundmark

Scott Delp

Alexander K Arrow

David Moore

Ananya Mitra

Joyce Huang

Brian Andrew Ellin

Frederic Moll

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

System and method for optogenetic therapy

Configurations are described for creating and using separable optical feedthroughs. These are especially useful in their at least semi-hermetic form when integrated with implantable photomedical devices. One embodiment is directed to a system for operatively coupling an optical output from a light source positioned inside of a sealed housing to an external optical fiber, comprising: a first optical fiber disposed adjacent to the light source and configured to receive at least a portion of the optical output; a second optical fiber operatively coupled to the first optical fiber and configured to capture at least a portion of an output from the first optical fiber; a primary seal operatively coupled to the housing between the light source and the second optical fiber that is at least partially transparent; and a secondary seal positioned between the second optical fiber and the environment.

Implantable optical feedthrough connector

Growing community of inventors

Belmont, CA, United States of America

Greg Stahler