University of Washington

Matchstick Technologies, Inc.

Liposonix, Inc.

Medicis Technologies Corporation

Greg P Darlington

Adam D Maxwell

Jens Ulrich Quistgaard

Charles S Desilets

Thomas J Matula

Jeffrey Robert Crunkilton

Brian E MacConaghy

Karol Bomsztyk

Brian E Macconaghy

Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting example, an illustrative piezoelectric element array assembly includes at least one piezoelectric element configured to produce ultrasound energy responsive to amplified driving pulses. A lens layer is bonded to the at least one piezoelectric element. The lens layer has a plurality of lenses formed therein that are configured to focus ultrasound energy created by single ones of the at least one piezoelectric element into a plurality of wells of a microplate disposable in ultrasonic communication with the lens layer, wherein more than one of the plurality of lenses overlie single ones of the at least one piezoelectric element.

Ultrasound system for shearing cellular material in a microplate

A physical shield placed on the face of a high intensity focused ultrasound transducer for medical applications is described. The shield may be shaped or angled to match a particular pattern of mechanical or acoustic energy that may damage the transducer during operation. The shield may be ablative, replaceable or modified as needed. Methods of manufacturing a transducer with a shield are also disclosed.

Transducer with shield

Growing community of inventors

Snohomish, WA, United States of America

Greg P Darlington