Nektar Therapeutics

Greg Lavaty

Antoni Kozlowski

Samuel P McManus

John R Handley

Anthony G Schaefer

Sachin Tipnis

David Swallow

Brian Bray

Seoju Lee

Bhalchandra V Joshi

Patrick Spence

Anthony O Chong

Shaoyong Nie

Patrick L Spence

Samuel Mcmanus

Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.

Alkoxylation methods

Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.

Salt form of a multi-arm polymer-drug conjugate

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Sugar Land, TX, United States of America

Greg Lavaty