Novartis Vaccines & Diagnostics, Gmbh

Chiron Corporation

Greg Harrowe

Joerg Kaufmann

Christoph Reinhard

Sanmao Kang

Hong Xin

Giulia C Kennedy

Anne B Jefferson

Vivien W Chan

Venkatakrishna Shyamala

Hamiduddin Khoja

Cristoph Reinhard

A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

Genes differentially expressed in breast cancer

The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

HX2004-6 polypeptide expressed in cancerous cells

The invention features methods for detection of metastatic and potentially metastatic cancerous cells by detection of expression of a gland-specific Ets transcription factor (GSEF) sequence, which encodes an Ets-domain containing protein. The invention also features methods and compositions for modulation of the polypeptide and/or gene activity for prophylactic and therapeutic purposes, such as inhibition of progression of a cell to a metastatic cancerous cell.

Methods for determining metastatic potential of breast cancer cells by detecting GSEF gene product expression

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Berkeley, CA, United States of America

Greg Harrowe