The University of Melbourne

Greg GuangHua Qiao

Eric Charles Reynolds

David Henry Solomon

Neil Martin O'Brien-Simpson

Anton Richard Blencowe

Shu Jie Lam

Simmi Abrol

Berkay Ozcelik

Georgia Patras

This invention relates to antibacterial compounds and compositions thereof. The invention also relates to the use of the compounds and compositions in methods of treating bacterial infections, particularly those bacterial infections including bacteria that exhibit antibiotic resistance. More specifically, the present invention provides a star shaped peptide polymer comprising a multifunctional core with a plurality of terminal arms extending therefrom, wherein the terminal arms are statistical or random peptide copolymers of at least a cationic amino acid residue and a hydrophobic amino acid residue.

Modified antibacterial compositions and methods

This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti-bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.

Antimicrobial composition combinations comprising star shaped peptide polymers

The disclosure relates to biodegradable polyether network polymers crosslinked via ester linkages, to substrates, implants and scaffolds comprising the biodegradable polyether network polymers, to methods for preparing such network polymers, implants and scaffolds, and to methods of using substrates, implants and scaffolds comprising the network polymers, particularly for culturing cells and regenerating tissue.

Biodegradable network polymers for regenerative medicine and tissue engineering

Polymer gels and methods for their preparation

A process for producing a microgel composition particles having a core of cross-linked polymer at a multiplicity of polymeric arms appended to the core, the process comprising reacting a living prepolymer component with a monomer component wherein the monomer component includes a multi-olefininc monomer.

Growing community of inventors

Melbourne, Australia

Greg GuangHua Qiao