Leland Stanford Junior University

Akzo Nobel N.v.

Greer M Murphy

Alan F Schatzberg

A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HTreceptor gene. This provides for a method to improve the treatment of an SSRI responsive disorder and in particular depression.

Method to determine the risk for side effects of an SSRI treatment in a person

This invention relates to methods for improving the therapeutic response of human patients with major depression by determining the apolipoprotein E genotype of a human patient and administering mirtazapine, in an amount effective to treat major depression, to those patients who are found to carry the gene for apolipoprotein E4. Also disclosed are methods for improving the therapeutic response of a human patient with major depression comprising administering mirtazapine, in an amount effective to treat major depression, to a human patient who is a carrier of the gene for apolipoprotein E4.

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Stanford, CA, United States of America

Greer M Murphy