Zambon S.p.a.

Dipharma S.p.a.

Zambon Group S.p.a.

Enichem Synthesis S.p.a

Dinamite Dipharma S.p.a.

Nicox S.a.

Blaschim S.p.a.

Cerbios-pharma Sa

Hc-pharma Ag

American Home Products Corporation

Chemo Iberica, S.a.

Chemelectiva Srl

Zambon Group

Selego Ab

Abbreviated Dipharma S.p.a.

Graziano Castaldi

Claudio Giordano

Pietro Allegrini

Silvia Cavicchioli

Fulvio Uggeri

Gabriele Razzetti

Vittorio Lucchini

Mauro Gaboardi

Alberto Bologna

Erminio Oldani

Antonio Tarquini

Giuseppe Barreca

Marco Villa

Francesca Benedini

Tiziano Scubla

Fausto Gorassini

Marco Baratella

Marta Castaldi

Nevio Francescutti

Franco Pozzi

Simone Mantegazza

Dario Tentorio

Renzo Rossi

Caterina Napoletano

Lino Colombo

Giuseppe Pallanza

Claudio Pozzoli

Maurizio Paiocchi

Fiorenzo Renzi

Francesco Minisci

Silvio Iera

Vincenzo Cannata

Luciana Crisci

Marcello Rasparini

Giovanni Villa

Domenico Magrone

Daniele Donati

Michel Bernatchez

Roberto Rossi

Laura Russo

Gianpiero Ventimiglia

Mauro Ercoli

Pierre Giguere

Giancarlo Verardo

Lars Fredriksson

Carlo Restelli

Claudio Girodano

Luca Banfi

Sonja Bellomi

Sara Helmy

Giovanni Marras

Alessandro Baruto

Paola Geatti

Eleonora Porta

Nicoletta Toniutti

Sabrina Bianchi

Gianluca Galdi

Valter Castelvetro

Plietro Allegrini

Enrico Mariotti

Francesca Musumeci

Fabio De Moliner

The present invention relates to a process for the synthesis of cysteamine or a salt thereof.

Process for the preparation of a sulfur-amine

A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived fromto obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.

Process for the preparation of sofosbuvir

Sofosbuvir in crystalline Form &#x3b1;, process for its production and use in pharmaceutical compositions.

Sofosbuvir in crystalline form and process for its preparation

Novel retinoic acid derivatives and a process for their preparation are described.

Retinoid derivatives and process for their preparation

A process for the preparation of Erlotinib is disclosed in which the compound of formula (II)  and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.

Process for the preparation of erlotinib

The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.

Process and intermediates for the preparation of dasatinib

The present invention relates to a novel one step process for preparing cross-linked poly(allylamine) polymers or salts thereof using the novel cross-linking agent of Formula (IV). This invention also relates to the compound of Formula (IV) as well as to a process to obtain it. The cross-linked poly(allylamine) polymers of the invention are useful in medicine as substrate-binding polymers.

One step process for preparing cross-linked poly(allylamine) polymers

Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.

Intermediates for the preparation of pramipexole

A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.

Process for the purification of 1,4-butanediol mononitrate

A process for the preparation of compounds of formulaHO-A-ONO&#x2003;&#x2003;(I)wherein A is a C-Calkylene chainby nitration of the corresponding alkanediols with 'stabilized' nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

Process for the mononitration of alkanediols

A novel process for the preparation of valsartan and novel intermediates useful in the preparation thereof.

Process for the preparation of valsartan and intermediates thereof

A process for the preparation of phenyltetrazole derivatives of formula (II) wherein R and Y are as defined in the disclosure, by direct ortho-metallation of (tetrazol-5-&#x3b3;l)benzene. The compounds of formula (II) are useful intermediates for the preparation of angiotensin II antagonists. 

Process for the preparation of phenyltetrazole derivatives

A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C-Calkyl, aryl or aryl-C-Calkyl; comprising the reaction between a compound of formula (II) wherein Rand Rare independently hydrogen, C-Calkyl, aryl, aryl-C-Calkyl, or Rand R, taken together, form a &#x2014;(CH)&#x2014;V&#x2014;(CH)&#x2014; group, in which V is NRor C(R)wherein Ris hydrogen, C-Calkyl, aryl or aryl-C-Calkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which Rand Rare independently C-Calkyl, aryl or aryl-C-Calkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C-Calkyl, aryl or aryl-C-Calkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.

Process for the preparation of adapalene

A process for the preparation of compounds of formula (I):HO-A-ONO&#x2003;&#x2003;(I)wherein A is a C-Calkylene chain, the compounds of formula (I) being synthesized by nitration of the corresponding alkanediols with 'stabilized' nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

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Briona, Italy

Graziano Castaldi