International Society for Drug Development S.r.l.

Purytra Farmaceutici S.r.l.

Grazia Chiellini

Simona Rapposelli

Amedeo Columbano

Guido Puricelli

Andrea Perra

Sheraz Gul

Massimiliano Runfola

The invention concerns a compound of Formula (I) or a salt thereof, wherein Ris H, (C-C)alkyl or CF; Ris H, (C-C)alkyl or CF; A is CHCOOH, XCHCOOCHCH, XCHCOOH, XCHCHNH, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where Ris H, —CH, —CHCHor CHCO—, Ris H or —CH, R5 is H or —CH, and Ris H or —CH. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TRβ).

Thyromimetics with a biphenylmethane scaffold and their use

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Rosignano Solvay, Italy

Grazia Chiellini