Zymergen Inc.

Precigen, Inc.

Grayson Wawrzyn

Louis Clark

Xinhua Zhao

Zach Serber

James Kealey

Lily Yuin Chao

Kevin Lee Dietzel

Na Trinh

Mark Anton Held

Patrick J Westfall

Jeffrey Orth

Matthias Helmut Schmalisch

Xuezhi Li

Warren Lau

Christopher Cheyney Farwell

Savita Ganesan

Fern R McSorley

Christine Roche

Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as isobutanol are disclosed. For example, genetically modified methanotrophs that are capable of generating isobutanol at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

Methods and microorganisms for the fermentation of methane to multi-carbon compounds

Genetically modified microorganisms that have the ability to convert carbon substrates into multicarbon products. Methods of making these genetically modified microorganisms and methods of using them. Vectors encoding enzymes for use in converting carbon substrates into multicarbon products.

The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone. The present disclosure also provides methods for engineering cells (e.g., microbial cells) to produce nepetalactone from a fermentation substrate such as glucose, as well as engineered cells having this capability and related cultures and methods for producing nepetalactone.

Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone

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Oakland, CA, United States of America

Grayson Wawrzyn